Ricercatore e docente in Chimica Farmaceutica

 

Brevetti (da ricercatore in Crinos S.p.A.)

1Procedimento per la preparazione di biopolimeri.

      G.Fedeli, G.Diamantini.

      brevetto di invenzione  It 21.04.87.

 

2A process for obtaining chemically defined and reproducible polydeoxyribonucleotid      Fedeli, Gianfranco; Diamantini, Giuseppe; Mantovani, Marisa; Prino, Giuseppe.

      PCT Int. Appl. (1987), 24 pp. WO 8706235 (C.A. 109:43442)  Application: WO 87-EP209. Priority: IT 86-20117.

 

3) A process for the preparation of monosialoganglioside by autolysis of cattle brain.

      Fedeli, Gianfranco; Diamantini, Giuseppe.

      Eur. Pat. Appl. (1989),  5 pp. EP  319890 (C.A. 112:73403)  Application: EP  88-120281. Priority: IT  87-22911.

  

4) Preparation of 2-trichloroacetoxy-3,4,5,6-tetrachlorobenzoic acid and compositions containing same for treating benign mammalian neoformations.

      Fedeli, Gianfranco; Diamantini, Giuseppe; Djaczenko, Wiktor; Strumillo, Maria.  (Italy).

      U.S.  (1989), 7 pp. Cont.-in-part of U.S. Ser. No. 815,092, abandoned. US  4871769 (C.A. 113:171687)  Application: US  87-11468  19870205. Priority: IT 84-48046; US  85-815092.

 

Pubblicazioni scientifiche (Crinos S.p.A.)

1) Absorption by the rat intestinal tract of fluorescein-labeled pig duodenal glycosaminoglycans.

      Pescador, R.; Diamantini, G.; Mantovani, M.; Malandrino, S.; Riva, A.; Casu, B.; Oreste, P.

      Arzneim.-Forsch. (1980), 30(11), 1893-6.

 

2)  Retention of antilipemic activity by periodate-oxidized non-anticoagulant heparins.

      Casu, B.; Diamantini, G.; Fedeli, G.; Mantovani, M.; Oreste, P.; Pescador, R.; Porta, R.; Prino, G.; Torri, G.; Zoppetti, G.

      Arzneim.-Forsch. (1986), 36(4),  637-42.

 

3The anticoagulant, hepatic lipase-releasing and lipoprotein lipase-releasing activities of several natural and chemically modified heparins differ.

      Pescador, Rodolfo; Porta, Roberto; Niada, Riccardo; Diamantini, Giuseppe; Fedeli, Gianfranco; Mantovani, Marisa.

      Biochem. Pharmacol. (1987), 36(2), 253-7.

 

47-Substituted theophylline.  Part V.  Azabenzhydrylaminoalkyl derivatives.

      Diamantini, G.; Spadoni, G.; Duranti, E.; Niada, R.

      Farmaco, Ed. Sci. (1987), 42(8), 561-6.

  

5Polymorphism of an indomethacin derivative.

      Diamantini, G.; Fedeli, G.; Niada, R.; Mantovani, M.

      Farmaco, Ed. Prat. (1988), 43(6),  201-12.

 

6Biopolymer preparation by an integrated dynamic enzymic membrane reactor:  technical and economic analysis.

      Fedeli, G. F.; Diamantini, G.; Drioli, E.

      Chim. Oggi  (1987), (9), 43-7.

 

7Profibrinolytic activities of chemically modified heparins with very low anticoagulant activities.

      Porta, R.; Pescador, R.; Niada, R.; Diamantini, G.; Fedeli, G. F.; Mantovani, M.; Prino, G.

      Thromb. Res. (1989), 53(5), 435-45.

  

8) Amides of b-(4-chlorophenoxy)-a-phenylethylamines are inhibitors of cholesterol biosynthesis in vitro.

      Rossi, S.; Diamantini, G.; Pescador, R.

      Farmaco (1989), 44(3), 315-21.

  

9) 7-Substituted theophyllines. Part VI. N-[2-(4-Chlorophenoxy)-1-phenyl-alkyl]-alkylamido derivatives.

      Diamantini, G.; Spadoni, G.; Salvatori, A.; Duranti, E.; Pescador, R.

      Farmaco (1990), 45(6), 665-72.

 

Pubblicazioni scientifiche (UniversitÓ degli Studi di Urbino Carlo Bo)

1) Nitroisoxazoles by manganese(IV) oxide oxidation of nitro-4,5-dihydro-isoxazoles.

      Diamantini, Giuseppe; Duranti, Ermanno; Tontini, Andrea.

      Synthesis (1993),  (11), 1104-8.

 

2) A new synthesis of 2-substituted DL-tryptophan derivatives.

      Balsamini, Cesarino; Diamantini, Giuseppe; Duranti, Andrea; Spadoni, Gilberto; Tontini, Andrea.

      Synthesis (1995),  (4), 370-2.

 

3) Electron impact ionization and fast atom bombardment mass spectrometry of some 3,3-dimethyl-1-(isoxazol-3-yl)triazenes, a new class of potential anticancer agents.

      Orsatti, Laura; Seraglia, Roberta; Traldi, Pietro; Diamantini, Giuseppe; Tarzia, Giorgio; Tontini, Andrea.

      J. Mass Spectrom. (1995), 30(11), 1567-73.

 

4) Correlation of the mutagenic properties of aryl- and heteroaryltriazenes with their electron ionization induced fragmentation.

      Tarzia, Giorgia; Diamantini, Giuseppe; Tontini, Andrea; Favretto, Donata; Traldi, Pietro.

      Rapid Commun. Mass Spectrom. (1996), 10(9), 1156-1158.

 

5) Synthesis of 1-(isoxazol-3-yl)triazene derivatives. Antimetastatic activity of 3,3-dimethyl-1-(5-methylisoxazol-3-yl)triazene.

      Tontini, A.; Diamantini, G.; Balsamini, C.; Tarzia, G.; Perissin, L.; Rapozzi, V

      Eur. J. Med. Chem. (1996), 31(9), 735-740.

 

6) Conformationally Restrained Melatonin Analogs: Synthesis, Binding Affinity for the Melatonin Receptor, Evaluation of the Biological Activity, and Molecular Modeling Study.

      Spadoni, Gilberto; Balsamini, Cesarino; Diamantini, Giuseppe; Giacomo, Barbara Di; Tarzia, Giorgio; Mor, Marco; Plazzi, Pier Vincenzo; Rivara, Silvia; Lucini, Valeria; Nonno, Romolo; Pannacci, Marilou; Fraschini, Franco; Stankov, Bojidar Michaylov.

      J. Med. Chem. (1997), 40(13), 1990-2002

 

7) 1-(2-Alkanamidoethyl)-6-methoxyindole Derivatives: A New Class of Potent Indole Melatonin Analogs.

      Tarzia, Giorgio; Diamantini, Giuseppe; Di Giacomo, Barbara; Spadoni, Gilberto; Esposti, Daniele; Nonno, Romolo; Lucini, Valeria; Pannacci, Marilou; Fraschini, Franco; Stankov, Bojidar Michaylov.

      J. Med. Chem. (1997), 40(13), 2003-2010

 

8) Correlation of the antimetastatic properties of aryltriazenes with their electron impact ionization mass spectrometry.

      Tarzia, Giorgio; Diamantini, Giuseppe; Tontini, Andrea; Bendini, Annalida; Favretto, Donata; Traldi, Pietro.

      Rapid Commun. Mass Spectrom. (1997), 11(12), 1365-1368

 

9) (E)-3-(2-(N-Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site Antagonists.

      Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Spadoni, Gilberto; Tontini, Andrea; Tarzia, Giorgio; DiFabio, Romano; Feriani, Aldo; Reggiani, Angelo; Tedesco, Giovanna; Valigi, Roberta.

      J. Med. Chem. (1998), 41(6), 808-820.

 

10) 2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

      Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Mor, Marco; Plazzi, Pier Vincenzo; Rivara, Silvia; Nonno, Romolo; Pannacci, Marilou; Lucini, Valeria; Fraschini, Franco; Stankov, Bojidar Michaylov.

      J. Med. Chem. (1998), 41(19), 3624-3634

 

11) Melatonin Receptor Ligands: Synthesis of New Melatonin Derivatives and Comprehensive Comparative Molecular Field Analysis (CoMFA) Study.

      Mor, Marco; Rivara, Silvia; Silva, Claudia; Bordi, Fabrizio; Plazzi, Pier Vincenzo; Spadoni, Gilberto; Diamantini, Giuseppe; Balsamini, Cesarino; Tarzia, Giorgio; Fraschini, Franco; Lucini, Valeria; Nonno, Romolo; Stankov, Bojidar Michaylov.

      J. Med. Chem. (1998), 41(20), 3831-3844

 

12) Metastable ion studies in the characterization of melatonin isomers.

      Diamantini, G.; Tarzia, G.; Spadoni, G.; D'Alpaos, M.; Traldi, P.

      Rapid Commun. Mass Spectrom. (1998), 12(20), 1538-1542

 

13) Rotation about the N2-N3 bond in 3,3-dimethyl-1-(isoxazol-3‑yl)triazenes.

      Tontini, Andrea; Gatti, Giuseppe; Diamantini, Giuseppe; Tarzia, Giorgio.

      J. Chem. Soc., Perkin Trans. 2 (1998),  (11), 2361-2363

 

14) N-acyl-5- and -2,5-substituted tryptamines: synthesis, activity and affinity for human mt1 and MT2 melatonin receptors.

      Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Carey, Aedin; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Nonno, Romolo; Lucini, Valeria; Pannacci, Marilou; Stankov, Bojidar Michaylov; Fraschini, Franco.

      Med. Chem. Res. (1998), 8(9), 487-498

 

15) Indole melatonin agonists and antagonists derived by shifting the melatonin side chain from the C-3 to the N-1 or to the C-2 indole position.

      Tarzia, Giorgio; Diamantini, Giuseppe; Spadoni, Gilberto.

      Biol. Signals Recept. (1999), 8(1-2), 24-31

 

16) 3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification.

      Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Spadoni, Gilberto; Tarzia, Giorgio; Tontini, Andrea; Di Fabio, Romano; Donati, Daniele.

      Farmaco (1999), 54(1-2), 101-111.

 

17) Design and synthesis of melatonin receptors agonists and antagonists.

      Tarzia, Giorgio; Diamantini, Giuseppe; Mor, Marco; Spadoni, Gilberto.

      Farmaco (2000), 55(3), 184-187

 

18) Antimetastatic action of a new analog of dacarbazine in mice bearing Lewis lung carcinoma.

      Perissin, Laura; Facchin, Patrizia; Bedini, Annalida; Diamantini, Giuseppe; Tontini, Andrea; Tarzia, Giorgio.

      Anticancer Res. (2000), 20(3A), 1513-1517

 

 19) Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

      Mor, M.; Spadoni, G.; Di Giacomo, B.; Diamantini, G.; Bedini, A.; Tarzia, G.; Plazzi, P. V.; Rivara, S.; Nonno, R.; Lucini, V.; Pannacci, M.; Fraschini, F.; Stankov, B. M.

      Bioorg. Med. Chem. (2001), 9(4), 1045-1057

 

20) 2-N-Acylaminoalkylindoles: Design and Quantitative Structure-Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists.

      Spadoni, Gilberto; Balsamini, Cesarino; Diamantini, Giuseppe; Tontini, Andrea; Tarzia, Giorgio; Mor, Marco; Rivara, Silvia; Plazzi, Pier Vincenzo; Nonno, Romolo; Lucini, Valeria; Pannacci, Marilou; Fraschini, Franco; Stankov, Bojidar Michaylov.

      J. Med. Chem. (2001), 44(18), 2900-2912

 

Pubblicazioni scientifiche pi¨ recenti

1: Sestili P, Diamantini G, Bedini A, Cerioni L, Tommasini I, Tarzia G, Cantoni O.
Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.
Biochem J. 2002 May 15;364(Pt 1):121-8.

2: Mor M, Spadoni G, Diamantini G, Bedini A, Tarzia G, Silva C, Vacondio F, Rivara M, Plazzi PV, Franceschini D, Zusso M, Giusti P.
Antioxidant and cytoprotective activity of indole derivatives related to melatonin.
Adv Exp Med Biol. 2003;527:567-75.

3: Mor M, Silva C, Vacondio F, Plazzi PV, Bertoni S, Spadoni G, Diamantini G, Bedini A, Tarzia G, Zusso M, Franceschini D, Giusti P.
Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities.
J Pineal Res. 2004 Mar;36(2):95-102.

4: Lucini V, Pannacci M, Scaglione F, Fraschini F, Rivara S, Mor M, Bordi F, Plazzi PV, Spadoni G, Bedini A, Piersanti G, Diamantini G, Tarzia G.
Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.
J Med Chem. 2004 Aug 12;47(17):4202-12.

5: Spadoni G, Diamantini G, Bedini A, Tarzia G, Vacondio F, Silva C, Rivara M, Mor M, Plazzi PV, Zusso M, Franceschini D, Giusti P.
Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.
J Pineal Res. 2006 Apr;40(3):259-69.

6: Rivara S, Diamantini G, Di Giacomo B, Lamba D, Gatti G, Lucini V, Pannacci M, Mor M, Spadoni G, Tarzia G.
Reassessing the melatonin pharmacophore-enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue.
Bioorg Med Chem. 2006 May 15;14(10):3383-91.

7: Fiorani M, Accorsi A, Blasa M, Diamantini G, Piatti E.
Flavonoids from italian multifloral honeys reduce the extracellular ferricyanide in human red blood cells.
J Agric Food Chem. 2006 Oct 18;54(21):8328-34.

8: Radogna F, Paternoster L, Albertini MC, Cerella C, Accorsi A, Bucchini A, Spadoni G, Diamantini G, Tarzia G, De Nicola M, D'Alessio M, Ghibelli L.
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells.
J Pineal Res. 2007 Sep;43(2):154-62.

9: Spadoni G, Bedini A, Diamantini G, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Caronno A, Fraschini F.
Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists.
ChemMedChem. 2007 Dec;2(12):1741-9.

10: Campana R, Patrone V, Franzini IT, Diamantini G, Vittoria E, Baffone W.
Antimicrobial activity of two propolis samples against human Campylobacter jejuni.
J Med Food. 2009 Oct;12(5):1050-6.

11: Lucarini S, Bartoccini F, Battistoni F, Diamantini G, Piersanti G, Righi M, Spadoni G.
A novel one-pot approach of hexahydropyrrolo[2,3-b]indole nucleus by a cascade addition/cyclization strategy: synthesis of (+/-)-esermethole.
Org Lett. 2010 Sep 3;12(17):3844-7.

12: Rivara S, Piersanti G, Bartoccini F, Diamantini G, Pala D, Riccioni T, Stasi MA, Cabri W, Borsini F, Mor M, Tarzia G, Minetti P.
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
J Med Chem. 2013 Feb 14;56(3):1247-61.

13: Salucci S, Burattini S, Giordano FM, Lucarini S, Diamantini G, Falcieri E.
Further Highlighting on the Prevention of Oxidative Damage by Polyphenol-Rich Wine Extracts.
J Med Food. 2017 Apr;20(4):410-419.

14: Antonini E, Diamantini G, Ninfali P. The effect of mechanical processing on avenanthramide and phenol levels in two organically grown Italian oat cultivars.
J Food Sci Technol. 2017 Jul;54(8):2279-2287.